Chen Min, Lee Chin Peng, Tang Rebecca, Chan Ben, Ou Chun Quan, Tang Mary Hoi Yin
Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.
Prenat Diagn. 2006 Aug;26(8):703-6. doi: 10.1002/pd.1484.
Absence of the nasal bone in fetuses with trisomy 21 is a potential ultrasound marker for Down syndrome from the first trimester onwards. Racial differences in fetal nasal bone length have been reported. There was no reference range for the first-trimester fetal nasal bone length (NBL) in the Chinese population.
From January 2002 to February 2005, we investigated the reference range of NBL in 2169 singleton fetuses whose parents were Chinese with normal pregnancy outcome. Ultrasound measurements of NBL were performed on a midsagittal plane at 12-14 weeks' gestation.
The nasal bone length measurement showed a significant increase with gestational age (GA) (p < 0.05). A linear relationship between nasal bone length and gestational age (NBL = -3.3462 x GA + 0.627, R(2) = 0.30, p < 0.001) as well as a linear relationship between nasal bone length and crown-rump length (CRL) (NBL = 0.3741 x CRL + 0.284, R(2) = 0.30, P < 0.001) was established.
The measurement of nasal bone length was feasible in the first trimester. The reference range of NBL in normal Chinese fetuses in the first-trimester of pregnancy was established. This formed a basis for further study on the use of fetal nasal bone measurement in the screening for aneuploidy in the Chinese population.
21三体胎儿鼻骨缺失是孕早期起唐氏综合征的一个潜在超声标志物。已有报道胎儿鼻骨长度存在种族差异。中国人群中尚无孕早期胎儿鼻骨长度（NBL）的参考范围。
2002年1月至2005年2月，我们调查了2169例父母为中国籍且妊娠结局正常的单胎胎儿的NBL参考范围。在妊娠12 - 14周时于正中矢状面进行NBL的超声测量。
鼻骨长度测量显示随孕周（GA）显著增加（p < 0.05）。建立了鼻骨长度与孕周之间的线性关系（NBL = -3.3462×GA + 0.627，R² = 0.30，p < 0.001）以及鼻骨长度与头臀长（CRL）之间的线性关系（NBL = 0.3741×CRL + 0.284，R² = 0.30，P < 0.001）。
孕早期测量鼻骨长度是可行的。建立了中国正常胎儿孕早期NBL的参考范围。这为进一步研究利用胎儿鼻骨测量在中国人群中筛查非整倍体奠定了基础。
