Stock Philippe, Akbari Omid, Berry Gerald, Freeman Gordon J, Dekruyff Rosemarie H, Umetsu Dale T
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305-5208, USA.
Nat Immunol. 2004 Nov;5(11):1149-56. doi: 10.1038/ni1122. Epub 2004 Sep 26.
The range of regulatory T cell (T(R) cell) types that control immune responses is poorly understood. We describe here a population of T(R) cells that developed in vivo from naive CD4(+)CD25(-) T cells during a T helper type 1 (T(H)1)-polarized response, distinct from CD25(+) T(R) cells. These antigen-specific T(R) cells were induced by CD8alpha(+) DCs, produced both interleukin 10 and interferon-gamma, and potently inhibited the development of airway hyper-reactivity. These T(R) cells expressed the transcription factors Foxp3 and T-bet, indicating that these T(R) cells are related to T(H)1 cells. Thus, adaptive T(R) cells are heterogeneous and comprise T(H)1-like T(R) cells as well as previously described T(H)2-like T(R) cells, which express Foxp3 and are induced during the development of respiratory tolerance by CD8alpha(-) DCs.
人们对控制免疫反应的调节性T细胞（T(R)细胞）类型范围了解甚少。我们在此描述了一类T(R)细胞群体，它们在1型辅助性T细胞（T(H)1）极化反应过程中由初始CD4(+)CD25(-) T细胞在体内发育而来，与CD25(+) T(R)细胞不同。这些抗原特异性T(R)细胞由CD8alpha(+)树突状细胞诱导产生，同时分泌白细胞介素10和干扰素-γ，并能有效抑制气道高反应性的发展。这些T(R)细胞表达转录因子Foxp3和T-bet，表明这些T(R)细胞与T(H)1细胞相关。因此，适应性T(R)细胞具有异质性，包括T(H)1样T(R)细胞以及先前描述的T(H)2样T(R)细胞，后者表达Foxp3，并在由CD8alpha(-)树突状细胞诱导的呼吸耐受过程中产生。
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