Pettigrew Melinda M
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034, USA.
Trends Biotechnol. 2004 Oct;22(10):491-3. doi: 10.1016/j.tibtech.2004.08.008.
Methods for comparing gene frequencies across large, epidemiologically defined bacterial collections are limited. A novel microarray technology has been developed called 'library on a slide'. In this technology, hundreds of entire microbial genomes are arrayed, rather than sequences of a single genome or sets of genes. These slides can then be probed for the presence of specific genes allowing researchers to draw inferences regarding important differences between related strains that differ in their pathogenic potential.
比较大型流行病学定义的细菌集合中基因频率的方法有限。一种名为“玻片上的文库”的新型微阵列技术已经开发出来。在这项技术中,排列的是数百个完整的微生物基因组,而不是单个基因组或基因集的序列。然后可以用这些玻片检测特定基因的存在,从而使研究人员能够推断出具有不同致病潜力的相关菌株之间的重要差异。