Raskin David M, Seshadri Rekha, Pukatzki Stefan U, Mekalanos John J
Department of Microbiology & Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.
Cell. 2006 Feb 24;124(4):703-14. doi: 10.1016/j.cell.2006.02.002.
The availability of hundreds of bacterial genome sequences has altered the study of bacterial pathogenesis, affecting both design of experiments and analysis of results. Comparative genomics and genomic tools have been used to identify virulence factors and genes involved in environmental persistence of pathogens. However, a major stumbling block in the genomics revolution has been the large number of genes with unknown function that have been identified in every organism sequenced to date.
数百种细菌基因组序列的可得性改变了细菌致病机制的研究，对实验设计和结果分析都产生了影响。比较基因组学和基因组工具已被用于识别毒力因子以及与病原体在环境中存活相关的基因。然而，基因组学革命中的一个主要障碍是，在迄今已测序的每个生物体中都发现了大量功能未知的基因。
Zotero 插件