Bompard Guillaume, Caron Emmanuelle
School of Biosciences, Division of Molecular Cell Biology, University of Birmingham, Birmingham B15 2TT, England, UK.
J Cell Biol. 2004 Sep 27;166(7):957-62. doi: 10.1083/jcb.200403127.
Despite their homology, the regulation of WASP and WAVE, activators of Arp2/3-dependent actin polymerization, has always been thought to be different. Several recent studies have revealed new aspects of their regulation, highlighting its complexity and the crucial role of post-translational modifications. New data also suggest additional functions for WASP family proteins, pushing us to reconsider existing models.
尽管WASP和WAVE具有同源性,但一直以来人们都认为它们作为Arp2/3依赖性肌动蛋白聚合的激活剂,其调控方式是不同的。最近的几项研究揭示了它们调控的新方面,突出了其复杂性以及翻译后修饰的关键作用。新数据还表明WASP家族蛋白具有其他功能,促使我们重新审视现有模型。