Meng Xue-mei, Yu Shi-feng
Department of Oral Pathology, Peking University School of Stomatology, Beijing 100081, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2004 Jul;39(4):294-7.
To detect the expression of a disintegrin-like and metalloproteinase (ADAM) 8 and 12 gene in the giant cell lesions of jaw and to study their effects on the histogenesis of cells in these lesions.
ADAM8 and ADAM12 was detected by immunohistochemistry (SP) in 40 paraffin-embedded specimens of central giant cell lesions of jaw, 10 peripheral giant cell lesions, 9 cherubisms, 6 aneurysmal bone cysts.
ADAM8 and ADAM12 were positive in the cytomembrane and cytoplasm of all multinucleated giant cells and some round mononuclear cells of the lesions; ADAM12 was positive for some spindle mononuclear stromal cells in central and peripheral giant cell lesions.
Multinucleated giant cells probably originated from the fusion of the round mononuclear cells, and ADAM8 and ADAM12 were involved in this process. In addition, ADAM12 might play a role in the maturation of spindle mononuclear stromal cells.
检测去整合素样金属蛋白酶（ADAM）8和12基因在颌骨巨细胞病变中的表达，并研究其对这些病变中细胞组织发生的影响。
采用免疫组织化学（SP）法检测40例颌骨中央巨细胞病变、10例周围巨细胞病变、9例 cherubism病、6例动脉瘤性骨囊肿石蜡包埋标本中的ADAM8和ADAM12。
ADAM8和ADAM12在病变中所有多核巨细胞及部分圆形单核细胞的细胞膜和细胞质中呈阳性；ADAM12在中央和周围巨细胞病变中的部分梭形单核基质细胞中呈阳性。
多核巨细胞可能起源于圆形单核细胞的融合，ADAM8和ADAM12参与了这一过程。此外，ADAM12可能在梭形单核基质细胞的成熟过程中发挥作用。
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