PGC-1α：增强线粒体功能
PGC-1alpha: turbocharging mitochondria.
作者信息
Houten Sander M, Auwerx Johan
机构信息
Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, 1 Rue Laurent Fries, 67404 Illkirch, France.
出版信息
Cell. 2004 Oct 1;119(1):5-7. doi: 10.1016/j.cell.2004.09.016.
PMID:15454076
Abstract
PGC-1alpha plays essential and diverse functions in the control of metabolism ranging from mitochondrial biogenesis and respiration to hepatic gluconeogenesis and muscle fiber-type switching. In a paper in this issue of Cell, the characterization of PGC-1alpha(-/-) mice illustrates these pleiotropic functions and reveals an unexpected role for PGC-1alpha in the brain.
摘要
PGC-1α在代谢调控中发挥着至关重要且多样的功能，涵盖从线粒体生物合成与呼吸作用到肝脏糖异生以及肌肉纤维类型转换等多个方面。在本期《细胞》杂志发表的一篇论文中，对PGC-1α基因敲除小鼠的特征描述阐释了这些多效性功能，并揭示了PGC-1α在大脑中出人意料的作用。
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