Seq2Struct：一个用于建立序列-结构联系的资源。
Seq2Struct: a resource for establishing sequence-structure links.
作者信息
Via Allegra, Zanzoni Andreas, Helmer-Citterich Manuela
机构信息
Department of Biology, Centre for Molecular Bioinformatics, University of Rome Tor Vergata 00133 Rome, Italy.
出版信息
Bioinformatics. 2005 Feb 15;21(4):551-3. doi: 10.1093/bioinformatics/bti049. Epub 2004 Sep 28.
UNLABELLED
Several methods for establishing cross-links between Protein Data Bank (PDB) structures or Structural Classification of Proteins (SCOP) domains and Swiss-Prot + TrEMBL sequences (or vice versa) rely on database annotations. Alternatively, sequence alignment procedures can be used. In this study, we describe Seq2Struct, a web resource for the identification of sequence-structure links. The resource consists of an exhaustive collection of annotated links between Swiss-Prot + TrEMBL and PDB + SCOP database entries. Links are based on pre-established highly reliable thresholds and stored in a relational database, which has been enhanced using annotations derived from Swiss-Prot, PDB, SCOP, GOA and DSSP databases. The Seq2Struct database contents, supported by a WWW web interface, can be queried both online and downloaded.
AVAILABILITY
The Seq2Struct resource, with related documentation, is available at http://surface.bio.uniroma2.it/seq2struct/
CONTACT
未标注
在蛋白质数据库（PDB）结构或蛋白质结构分类（SCOP）结构域与瑞士蛋白质数据库+TrEMBL序列之间建立交叉链接（反之亦然）的几种方法依赖于数据库注释。另外，也可以使用序列比对程序。在本研究中，我们描述了Seq2Struct，这是一个用于识别序列-结构链接的网络资源。该资源包含瑞士蛋白质数据库+TrEMBL与PDB+SCOP数据库条目之间注释链接的详尽集合。链接基于预先设定的高度可靠阈值，并存储在关系数据库中，该数据库已使用源自瑞士蛋白质数据库、PDB、SCOP、基因本体注释（GOA）和蛋白质二级结构预测（DSSP）数据库的注释进行了增强。通过万维网网络界面支持的Seq2Struct数据库内容既可以在线查询，也可以下载。
可用性
Seq2Struct资源及相关文档可在http://surface.bio.uniroma2.it/seq2struct/获取。
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