Frater John L, Batanian Jacqueline R, O'Connor Dennis M, Grosso Leonard E
Department of Pathology, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA.
J Pediatr Hematol Oncol. 2004 Oct;26(10):672-7.
Lymphoblastic leukemias with surface immunoglobulin light chain expression and L1/L2 blast morphology (French-American-British Classification) are rare. The poor prognosis of lymphoblastic leukemia in children under 1 year of age is attributed largely to rearrangements involving the mixed lineage leukemia (mll, also known as all1, htrx, trx1, or hrx) gene that occur with increased frequency in this population. Mll-rearranged cases with a mature B-cell phenotype are rare. The authors describe an infant with mature B-cell lymphoblastic leukemia with an mll rearrangement and L1/L2 cytomorphology and discuss the clinical, genetic, and immunophenotypic features in the context of previously reported cases.
具有表面免疫球蛋白轻链表达及L1/L2原始细胞形态（法国-美国-英国分类法）的淋巴细胞白血病较为罕见。1岁以下儿童淋巴细胞白血病预后较差，很大程度上归因于混合谱系白血病（mll，也称为all1、htrx、trx1或hrx）基因重排，该重排在这一人群中出现频率增加。具有成熟B细胞表型的mll重排病例罕见。作者描述了1例具有mll重排、L1/L2细胞形态的成熟B细胞淋巴细胞白血病婴儿，并结合既往报道病例讨论了其临床、遗传及免疫表型特征。
