Norrving Bo, Hydén Dag
Neurologiska kliniken, Universitetssjukhuset i Lund, Sweden.
Lakartidningen. 2004 Sep 2;101(36):2728-30, 2732, 2734.
Studies with MRI and non-invasive vascular imaging have modified previous conceptions on clinical spectrum and causes of different types of brain stem infarcts. Wallenberg's syndrome caused by lateral medullary infarction (LMI) often presents with patterns of sensory loss different from the "classical" crossed type. LMI carries a risk for respiratory and cardiovascular complications in the acute phase, warranting close patient monitoring. Medial medullary infarcts often present with a lacunar syndrome mimicking capsular or pontine small vessel disease. Cerebellar infarcts are most often caused by cardiac embolism. Isolated vertigo may be the only presenting symptom. Neurosurgical intervention of expansive cerebellar infarcts may be life-saving. Clinical features of progressive multifocal brain-stem symptoms are often suggestive of basilar artery occlusion. CT-angiography is a useful initial diagnostic tool. Based on observational studies, intraarterial thrombolysis is used in selected patients with basilar artery occlusion, but further studies are needed to define treatment criteria more precisely.
磁共振成像(MRI)和非侵入性血管成像研究改变了先前关于不同类型脑干梗死的临床谱和病因的观念。由延髓外侧梗死(LMI)引起的延髓背外侧综合征(Wallenberg综合征)通常表现出与“经典”交叉型不同的感觉丧失模式。LMI在急性期有呼吸和心血管并发症的风险,需要密切监测患者。延髓内侧梗死常表现为类似囊腔或脑桥小血管病的腔隙综合征。小脑梗死最常见的病因是心脏栓塞。孤立性眩晕可能是唯一的首发症状。对扩张性小脑梗死进行神经外科干预可能挽救生命。进行性多灶性脑干症状的临床特征常提示基底动脉闭塞。CT血管造影是一种有用的初始诊断工具。基于观察性研究,动脉内溶栓用于选定的基底动脉闭塞患者,但需要进一步研究以更精确地确定治疗标准。