乙型肝炎免疫球蛋白对阻断HBV宫内感染的作用。
Effect of hepatitis B immunoglobulin on interruption of HBV intrauterine infection.
作者信息
Li Xiao-Mao, Shi Min-Feng, Yang Yue-Bo, Shi Zhong-Jie, Hou Hong-Ying, Shen Hui-Min, Teng Ben-Qi
机构信息
Department of Obstetrics and Gynecology, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China.
出版信息
World J Gastroenterol. 2004 Nov 1;10(21):3215-7. doi: 10.3748/wjg.v10.i21.3215.
AIM
To evaluate the efficacy of hepatitis B immunoglobulin (HBIG) in interrupting hepatitis B virus (HBV) intrauterine infection during late pregnancy.
METHODS
We allocated 112 HBsAg positive pregnant women into 2 groups randomly. Fifty seven cases in the HBIG group received 200 IU (unit) HBIG intramuscularly every 4 wk from the 28 wk of gestation to the time of delivery, while 55 cases in the control group received no special treatment. HBsAg, HBeAg, HBcAb, HBeAb, HBsAb and HBV DNA levels were tested in the peripheral blood specimens from all of the mothers at 28 wk of gestation, just before delivery, and in blood from their newborns within 24 h before administration of immune prophylaxis.
RESULTS
The intrauterine infection rate in HBIG group and control group were 10.5% and 27.3%, respectively, with significant difference (P<0.05). It showed ascendant trend as HBV DNA levels in the peripheral blood increased before delivery.
CONCLUSION
HBIG is potent to cut down HBV intrauterine infection rate significantly when administered to pregnant women regularly during late pregnancy. The possibility of HBV intrauterine infection increases if maternal blood HBV DNA> or =10(8) copies/mL.
目的
评估乙肝免疫球蛋白（HBIG）在妊娠晚期阻断乙肝病毒（HBV）宫内感染的疗效。
方法
将112例HBsAg阳性孕妇随机分为2组。HBIG组57例孕妇自妊娠28周起至分娩时，每4周肌肉注射200国际单位（IU）HBIG，而对照组55例孕妇未接受特殊治疗。在妊娠28周、临分娩前采集所有母亲的外周血标本，以及在新生儿进行免疫预防给药前24小时内采集其血液标本，检测其中HBsAg、HBeAg、HBcAb、HBeAb、HBsAb和HBV DNA水平。
结果
HBIG组和对照组的宫内感染率分别为10.5%和27.3%，差异有统计学意义（P<0.05）。临分娩前外周血中HBV DNA水平升高时，宫内感染率呈上升趋势。
结论
妊娠晚期对孕妇定期使用HBIG可显著降低HBV宫内感染率。如果孕妇血液中HBV DNA≥10⁸拷贝/mL，HBV宫内感染的可能性增加。
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