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[乙型肝炎病毒的母婴传播。问题现状与预防]

[Mother-child transmission of hepatitis B virus. State of the problem and prevention].

作者信息

Hamdani-Belghiti S, Bouazzaou N L

机构信息

Service de néonatologie, hôpital d'enfants de Rabat, CHU Avicenne, Maroc.

出版信息

Arch Pediatr. 2000 Aug;7(8):879-82. doi: 10.1016/s0929-693x(00)80199-2.

Abstract

Hepatitis B virus (HBV) infection is a worldwide problem of public health. Mother/child transmission of the virus represents a major factor in maintaining the infection, which is often transmitted during delivery, the risk of transmission of the HBV depending on the degree of maternal infectiosity, the genomic type of the virus, and the rate of maternal antibodies. Evolution towards chronicity of the infected newborn is frequent. The available means to prevent the mother/child transmission of the virus are efficient. Once HBV maternal infection is diagnosed during pregnancy, joint administration of vaccine and specific immunoglobulins to the baby in the early neonatal period efficiently prevent the mother/child transmission of the virus.

摘要

乙型肝炎病毒(HBV)感染是一个全球性的公共卫生问题。该病毒的母婴传播是维持感染的一个主要因素,通常在分娩期间传播,HBV的传播风险取决于母亲的感染程度、病毒的基因组类型以及母亲抗体的水平。受感染新生儿发展为慢性感染的情况很常见。现有的预防该病毒母婴传播的方法是有效的。一旦在孕期诊断出母亲感染HBV,在新生儿早期联合给婴儿接种疫苗和特异性免疫球蛋白可有效预防该病毒的母婴传播。

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