保持完整性。
Maintaining integrity.
作者信息
Shiloh Yosef, Lehmann Alan R
机构信息
The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
出版信息
Nat Cell Biol. 2004 Oct;6(10):923-8. doi: 10.1038/ncb1004-923.
Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degenerative conditions. Current progress in this rapidly expanding field was the subject of an EMBO workshop, Maintenance of Genomic Integrity, that took place in June 2004 in Galway, Ireland. Top
目前，关于基因组稳定性和完整性的研究已远远超出DNA修复的生物化学范畴，涵盖了涉及细胞生命诸多方面的信号转导途径。基因组完整性途径紊乱可导致使人衰弱的遗传疾病、早衰、易患癌症和退行性疾病。2004年6月在爱尔兰戈尔韦举行的欧洲分子生物学组织（EMBO）研讨会“基因组完整性的维持”的主题就是这一快速发展领域的当前进展。顶级
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