Franchitto Annapaola
Section of Experimental and Computational Carcinogenesis, Istituto Superiore di Sanità, Rome, Italy.
Ital J Biochem. 2007 Jun;56(2):115-21.
In recent years growing evidence has suggested that the RecQ helicases play a crucial role in preserving genome stability. The importance of this observation in humans is substantiated by the fact that the absence of a functional RecQ helicase is associated with genetic syndromes characterised by elevated predisposition to a wide variety of cancers. It is well recognized that maintenance of genome integrity relies on the accurate execution of the DNA replication process as well as on efficient DNA repair. A number of studies have described interactions of RecQ helicases with topoisomerases and it has been proposed that this cooperation may be essential for cell viability and the avoidance of cancer development in human cells.
近年来，越来越多的证据表明，RecQ解旋酶在维持基因组稳定性方面起着至关重要的作用。这一观察结果在人类中的重要性得到了证实，即缺乏功能性RecQ解旋酶与遗传综合征相关，这些综合征的特征是易患多种癌症。众所周知，基因组完整性的维持依赖于DNA复制过程的准确执行以及有效的DNA修复。许多研究描述了RecQ解旋酶与拓扑异构酶的相互作用，有人提出这种合作对于细胞活力和避免人类细胞中癌症的发生可能至关重要。
