Deng Quan-jun, Mao Bo-yong, Zhang Shang-fu, Tang Jiang, Wang En-ren
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 Sep;35(5):641-3.
To gain an insight into the possible relationship between the expression of cyclooxygenase-2 (COX-2) and the prognosis of the patients with medulloblastoma.
COX-2 expression was investigated in 52 medulloblastoma and 10 normal cerebellar tissue specimens by immunohistochemistry. Kaplan-Meier analyses, Log-rank test, and Cox proportional hazard model were used to explore the relationship between the percentage of COX-2 expression and the survival period of patients with medulloblastoma.
Positive staining with COX-2 was either moderately or strongly observed in most of the medulloblastoma (51/52). Moreover, COX-2 was expressed not only in tumor cells, but also in the vascular endothelial cells of tumor. No COX-2 immunoreactivity was observed in normal cerebellar tissue. Kaplan-Meier analyses demonstrated that high COX-2 expression (> or = 50% of cells stained positive) correlated with poor survival for the study group as a whole (P < 0.0001).
Our study provides evidence that COX-2 is expressed in the majority of medulloblastomas and that a potential role of COX-2 inhibitors as an adjuvant therapy for brain tumors may exist.
深入了解环氧化酶-2（COX-2）的表达与髓母细胞瘤患者预后之间的可能关系。
采用免疫组织化学方法检测52例髓母细胞瘤组织标本和10例正常小脑组织标本中COX-2的表达情况。运用Kaplan-Meier分析、Log-rank检验和Cox比例风险模型，探讨COX-2表达百分比与髓母细胞瘤患者生存期之间的关系。
在大多数髓母细胞瘤（51/52）中观察到COX-2呈中度或强阳性染色。此外，COX-2不仅在肿瘤细胞中表达，还在肿瘤的血管内皮细胞中表达。在正常小脑组织中未观察到COX-2免疫反应性。Kaplan-Meier分析表明，COX-2高表达（≥50%的细胞染色阳性）与整个研究组的不良生存相关（P < 0.0001）。
我们的研究提供了证据表明COX-2在大多数髓母细胞瘤中表达，并且COX-2抑制剂作为脑肿瘤辅助治疗的潜在作用可能存在。
