[丙泊酚对离体人妊娠子宫肌的作用]
[The effect of propofol on isolated human pregnant uterine muscles].
作者信息
Luo Dong, Wang Quan-yun, Huang Wei, Lü Sheng, Kong Gu-ya
机构信息
Department of Anesthesiology, West China Second Hospital, Sichuan University, Chengdu, China.
出版信息
Sichuan Da Xue Xue Bao Yi Xue Ban. 2004 Sep;35(5):668-70.
OBJECTIVE
To investigate the effects of propofol on spontaneous contractions of isolated human pregnant myometrial smooth muscles.
METHODS
Twenty isolated human pregnant myometrial muscle strips with rhythmic spontaneous contraction were randomly divided into two groups: control group (n=10) and propofol group (n=10). In propofol group propofol was added cumulatively. The changes of uterine contraction were monitored.
RESULTS
Propofol at concentration of 0. 5 microg/ml and 2 microg/ml had no effect on the spontaneous contraction of isolated human pregnant uterine muscles; propofol at concentration of 5 microg/ml and 10 microg/ml could significantly reduce the spontaneous contraction of isolated human pregnant uterine muscles; the higher the concentration was, the more would be the reduction. The effect could be blocked by oxytocin (140 +/- 50) microU/ml.
CONCLUSION
Propofol could significantly reduce the spontaneous rhythmic contractions of isolated human pregnant myometrial smooth muscles in concentration-dependent manner. Oxytocin could antagonize the action.
目的
探讨丙泊酚对人离体妊娠子宫肌层平滑肌自发收缩的影响。
方法
选取20条具有节律性自发收缩的人离体妊娠子宫肌条，随机分为两组：对照组（n = 10）和丙泊酚组（n = 10）。丙泊酚组采用累积加药法，监测子宫收缩变化。
结果
0.5μg/ml和2μg/ml浓度的丙泊酚对人离体妊娠子宫肌自发收缩无影响；5μg/ml和10μg/ml浓度的丙泊酚可显著降低人离体妊娠子宫肌自发收缩，且浓度越高，降低越明显。该作用可被（140±50）μU/ml的缩宫素阻断。
结论
丙泊酚可呈浓度依赖性显著降低人离体妊娠子宫肌层平滑肌的自发节律性收缩。缩宫素可拮抗该作用。
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