Bae Hoon, Kim Hak Sung
Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, USA.
Arch Pharm Res. 2004 Aug;27(8):811-5. doi: 10.1007/BF02980170.
Coumarin and its derivatives occur widely in nature. Many attempts were made for synthesis of various coumarin derivatives because of their interesting biological activities. In this study, solid phase synthetic approach of 3-(4-hydroxyphenyl)coumarin was achieved for combinatorial synthesis of substituted 3-phenylcoumarin analogues. Starting from 4-hydroxyphenylacetic acid methyl ester, release of 3-(4-hydroxypnehyl)coumarin from polymer support was accomplished.
香豆素及其衍生物在自然界中广泛存在。由于其有趣的生物活性，人们进行了许多尝试来合成各种香豆素衍生物。在本研究中，实现了3-(4-羟基苯基)香豆素的固相合成方法，用于取代3-苯基香豆素类似物的组合合成。从4-羟基苯乙酸甲酯开始，完成了3-(4-羟基苯基)香豆素从聚合物载体上的释放。
