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一种提高最小模型在糖尿病研究和临床管理中与静脉葡萄糖耐量试验配合使用时的实用性的策略。

A strategy to enhance the usability of the minimal model as used with the intravenous glucose tolerance test in diabetes research and clinical management.

作者信息

Hayes Richard, Grimson Bill, Pacini Giovanni, Nolan John J

机构信息

Dublin Institute of Technology, Dublin, Ireland.

出版信息

Stud Health Technol Inform. 2002;90:519-24.

Abstract

The Minimal Model method of determining Insulin Sensitivity from the Intravenous glucose Tolerance Test is a valuable tool for the Diabetes research community. However the Minimal Model algorithm itself is not readily available in a user-friendly modem windows environment to the clinical researcher in many research departments. In addition use of the model often requires intervention by an experienced "modeller" to interpret the results produced by the method. This paper proposes a more readily available and usable version of the program and discusses the issues which surround the use of the program by clinical researchers without computer mathematical modelling experience.

摘要

通过静脉葡萄糖耐量试验测定胰岛素敏感性的最小模型方法,是糖尿病研究领域的一项重要工具。然而,对于许多研究部门的临床研究人员而言,最小模型算法本身在用户友好的现代Windows环境中并不容易获取。此外,使用该模型往往需要经验丰富的“建模者”进行干预,以解读该方法产生的结果。本文提出了一个更易于获取和使用的程序版本,并讨论了缺乏计算机数学建模经验的临床研究人员在使用该程序时所面临的问题。

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