与磷脂聚合物共混的醋酸纤维素中空纤维膜及其血液净化性能。

Cellulose acetate hollow fiber membranes blended with phospholipid polymer and their performance for hemopurification.

作者信息

Ye Sang Ho, Watanabe Junji, Ishihara Kazuhiko

机构信息

Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

出版信息

J Biomater Sci Polym Ed. 2004;15(8):981-1001. doi: 10.1163/1568562041526450.

DOI:10.1163/1568562041526450

PMID:15461185

Abstract

Commercially available hollow fiber membranes (HFMs) made from synthetic polymers, including cellulose acetate (CA) HFMs, used as hemopurification membranes, need to improve in hemocompatibility, by suppressing protein adsorption and clot formation. In this study, CA HFMs blended with 2-methacryloyloxyethyl phosphorylcholine (MPC) copolymer (PMB30 composed of MPC and n-butyl methacrylate (BMA)) were prepared by a dry-jet wet spinning process. Their performances were evaluated by characterizing their properties such as structure, permeability and protein adsorption. CA/PMB30-blend HFMs showed structure changes such as increase of porosity, development of large pores and decreasing of the thickness of the active layer. And the structure and permeability of CA/PMB30-blend HFMs were controllable by changing preparation conditions. Also, the CA/PMB30-blend HFMs had good permeability, low protein adsorption and low fouling property during the permeability experiment in comparison with CA HFMs, because the hydrophilic and hemocompatible MPC copolymer (PMB30) existed on the surface of the HFM.

摘要

市售的由合成聚合物制成的中空纤维膜（HFMs），包括醋酸纤维素（CA）HFMs，用作血液净化膜时，需要通过抑制蛋白质吸附和凝块形成来提高血液相容性。在本研究中，通过干喷湿纺工艺制备了与2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）共聚物（由MPC和甲基丙烯酸正丁酯（BMA）组成的PMB30）共混的CA HFMs。通过表征其结构、渗透性和蛋白质吸附等性能来评估它们的性能。CA/PMB30共混HFMs表现出结构变化，如孔隙率增加、大孔形成以及活性层厚度减小。并且CA/PMB30共混HFMs的结构和渗透性可通过改变制备条件来控制。此外，与CA HFMs相比，CA/PMB30共混HFMs在渗透性实验期间具有良好的渗透性、低蛋白质吸附和低污染特性，因为亲水性和血液相容性的MPC共聚物（PMB30）存在于HFM表面。