Lockwood D N, Weber J N
Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
Parasitol Today. 1989 Oct;5(10):310-6. doi: 10.1016/0169-4758(89)90121-x.
'Illnesses no one's got' was the epidemiological clue that led to the identification of AIDS as a new disease in 1981 when a rare infectious organism Pneumocystis carinii was seen in previously healthy homosexuals. Since then a wide range of parasite infections has been recognized in AIDS patients. However, these patients are not susceptible to just any passing parasite. The human immunodeficiency virus (HIV) produces a specific immune defect and only parasites that can exploit that defect will be able to flourish. In this review Diana Lockwood and Jonathan Weber explore the spectrum of parasite diseases recognized in AIDS and also consider those parasites that occur infrequently in AIDS. Analysis of parasitic infections that AIDS patients do not suffer from will yield valuable information about immune recognition and handling of these parasites.
“无人患有的疾病”是一条流行病学线索，它使得艾滋病在1981年被确认为一种新疾病，当时在原本健康的同性恋者身上发现了一种罕见的传染性生物体——卡氏肺孢子虫。从那时起，艾滋病患者中已被确认存在多种寄生虫感染。然而，这些患者并非对任何偶然出现的寄生虫都易感。人类免疫缺陷病毒（HIV）会导致特定的免疫缺陷，只有那些能够利用这种缺陷的寄生虫才能大量繁殖。在这篇综述中，戴安娜·洛克伍德和乔纳森·韦伯探讨了艾滋病中已被确认的寄生虫病谱，同时也考虑了那些在艾滋病中不常见的寄生虫。对艾滋病患者未患有的寄生虫感染进行分析，将得出有关这些寄生虫免疫识别和处理的有价值信息。
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