Hajduk S L, Hager K, Esko J D
Department of Biochemistry, the University of Alabama at Birmingham, School of Medicine, Birmingham, AL 35294, USA.
Parasitol Today. 1992 Mar;8(3):95-8. doi: 10.1016/0169-4758(92)90247-y.
Nearly 90 years after the discovery that certain African trypanosornes were killed by normal human serum, we still do not understand how this innate trypanocidal factor works. Biochemical studies have provided us with an unlikely candidate: human high-density lipoprotein (HDL). This trypanosome lytic factor (TLF) from human serum is important since its activity restricts the host range of Trypanosoma brucei brucei, and the expression of this natural killing factor in cattle would represent a novel approach to the control of bovine tryponosomiasis. Here, Steve Hajduk, Kristin Hager and Jeffrey Esko discuss evidence for the TLF being a minor subclass of serum HDL and propose a mechanism for lysis based on the binding, endocytosis and lysosomal targeting of TLF.
在发现某些非洲锥虫能被正常人血清杀死近90年后，我们仍然不明白这种先天性杀锥虫因子是如何起作用的。生化研究为我们提供了一个不太可能的候选者：人类高密度脂蛋白（HDL）。来自人血清的这种锥虫溶解因子（TLF）很重要，因为其活性限制了布氏布氏锥虫的宿主范围，并且在牛中表达这种天然杀伤因子将代表一种控制牛锥虫病的新方法。在此，史蒂夫·哈杜克、克里斯汀·哈格和杰弗里·埃斯科讨论了TLF是血清HDL的一个小亚类的证据，并基于TLF的结合、内吞作用和溶酶体靶向提出了一种裂解机制。
