蓝氏贾第鞭毛虫的表面抗原变异性及变异

Surface antigen variability and variation in Giardia lamblia.

作者信息

Nash T

机构信息

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 126, Bethesda, MD 20892, USA.

出版信息

Parasitol Today. 1992 Jul;8(7):229-34. doi: 10.1016/0169-4758(92)90119-m.

DOI:10.1016/0169-4758(92)90119-m

PMID:15463623

Abstract

Recent studies show that Giardia isolates are heterogeneous but fall into at least three groups as determined by a number of complementary techniques. Giardia undergoes surface antigenic variation, both in vitro, and in humans and other animal model infections. Many of the characteristics of antigenic variation and the proteins involved, called variant-specific surface proteins (VSPs), are unique. The sequences of five VSPs reveal a family of cysteine-rich proteins. Here Theodore Nash reviews the relationship between antigenic variation and Giardia heterogeneity.

摘要

最近的研究表明，贾第虫分离株具有异质性，但通过多种互补技术确定，它们至少可分为三组。贾第虫在体外以及在人类和其他动物模型感染中都会发生表面抗原变异。抗原变异的许多特征以及所涉及的蛋白质，即所谓的变异特异性表面蛋白（VSPs），都是独特的。五种VSPs的序列揭示了一个富含半胱氨酸的蛋白质家族。在此，西奥多·纳什综述了抗原变异与贾第虫异质性之间的关系。