Melnick Susan M, Torres-Reveron Annelyn, Dow-Edwards Diana L
Laboratory of Cerebral Metabolism, Department of Physiology/Pharmacology, State University of New York, Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
Brain Res Dev Brain Res. 2004 Oct 15;153(1):127-34. doi: 10.1016/j.devbrainres.2004.07.010.
Developmental cocaine exposure produces long-term alterations in function of many neuronal circuits. This study examined glucose metabolic rates following repeated amphetamine administration in adult male and female rats pretreated with cocaine during postnatal days (PND) 11-20. PND11-20 cocaine increased the response to amphetamine in many components of the motor system and the dorsal caudate-putamen, in particular, and decreased the metabolic response in the hypothalamus. While amphetamine alone produced widespread increases in metabolism, there were no cocaine-related effects in the mesolimbic, limbic or sensory structures. These data suggest that a brief cocaine exposure during development can alter ontogeny and result in abnormal neuronal responses to repeated psychostimulant administration in adulthood.
发育期接触可卡因会对许多神经回路的功能产生长期改变。本研究检测了在出生后第11 - 20天（PND）用可卡因预处理的成年雄性和雌性大鼠反复给予苯丙胺后的葡萄糖代谢率。出生后第11 - 20天接触可卡因增加了运动系统许多组成部分，特别是背侧尾状核 - 壳核中对苯丙胺的反应，并降低了下丘脑的代谢反应。虽然单独使用苯丙胺会使代谢普遍增加，但在中脑边缘、边缘或感觉结构中未发现与可卡因相关的影响。这些数据表明，发育期短暂接触可卡因会改变个体发育，并导致成年期对反复给予精神兴奋剂产生异常的神经元反应。
