Kida Yasuyuki, Shiraishi Tomoki, Ogura Toshihiko
Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5, Takayama, Ikoma, Nara, 630-0101, Japan.
Brain Res Dev Brain Res. 2004 Oct 15;153(1):143-50. doi: 10.1016/j.devbrainres.2004.07.014.
Genes controlling the planar cell polarity (PCP) pathway have recently been described in Drosophila. Although a number of PCP-related genes were identified, it remains unknown whether the same genetic programs found in invertebrate embryos operate in vertebrate embryos, especially with regard to central nervous system development. To gain insights into the roles played by vertebrate PCP-related genes, we cloned and examined the expression patterns of chick and mouse homologues of the Xenopus Daam gene, an essential component of the PCP pathway and involved in the convergent extension movement of cells. The observed expression patterns in developing central nervous tissues suggested that vertebrate Daam genes were involved in pivotal steps in neuronal cell differentiation and movement.
控制平面细胞极性（PCP）通路的基因最近在果蝇中得到了描述。尽管已鉴定出许多与PCP相关的基因，但在脊椎动物胚胎中是否存在与无脊椎动物胚胎中相同的遗传程序仍不清楚，尤其是在中枢神经系统发育方面。为了深入了解脊椎动物PCP相关基因所起的作用，我们克隆并检测了非洲爪蟾Daam基因在鸡和小鼠中的同源基因的表达模式，该基因是PCP通路的一个重要组成部分，参与细胞的汇聚延伸运动。在发育中的中枢神经组织中观察到的表达模式表明，脊椎动物的Daam基因参与了神经元细胞分化和运动的关键步骤。
