Andersen Dana C, Reilly Dorothea E
Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Curr Opin Biotechnol. 2004 Oct;15(5):456-62. doi: 10.1016/j.copbio.2004.08.002.
In recent years, monoclonal antibodies have emerged as an increasingly important class of human therapeutics. A variety of forms of antibodies, including fragments such as Fabs, Fab'2s and single-chain Fvs, are also being evaluated for a range of different purposes. A variety of expression systems and improvements within these systems have been developed to address these growing and diverse needs.
近年来,单克隆抗体已成为一类日益重要的人类治疗药物。包括Fab、Fab'2和单链Fv等片段在内的多种抗体形式也正在针对一系列不同目的进行评估。为满足这些不断增长的多样化需求,已开发出多种表达系统及对这些系统的改进方法。