Friberg Jens, Scharling Henrik, Gadsbøll Niels, Truelsen Thomas, Jensen Gorm B
Department of Cardiovascular Medicine, Copenhagen City Heart Study, Bispebjerg University Hospital, Copenhagen, Denmark.
Am J Cardiol. 2004 Oct 1;94(7):889-94. doi: 10.1016/j.amjcard.2004.06.023.
The Copenhagen City Heart Study is a population-based cohort study. Using baseline data from 3 cohort examinations (1976 to 1978, 1981 to 1983, and 1991 to 1994), we analyzed the gender-specific effect of atrial fibrillation (AF) on the risk of stroke and cardiovascular death during 5 years of follow-up. Baseline data from 29,310 subjects were included. AF was documented in 276 subjects (110 women and 166 men). During a mean follow-up of 4.7 years, 635 strokes were identified, 35 of which occurred in subjects who had AF (22 women and 13 men). After adjustment for age and co-morbidity, the effect of AF on the risk of stroke was 4.6-fold greater in women (hazard ratio 7.8, 95% confidence interval 5.8 to 14.3) than in men (hazard ratio 1.7, 95% confidence interval 1.0 to 3.0). Cardiovascular death occurred in 1,122 subjects, 63 of whom had AF (28 in women and 35 in men). The independent effect of AF on cardiovascular mortality rate was 2.5-fold greater in women (hazard ratio 4.4, 95% confidence interval 2.9 to 6.5) than in men (hazard ratio 2.2, 95% confidence interval 1.6 to 3.1). Our results indicate that AF is a much more pronounced risk factor for stroke and cardiovascular death in women than in men.
哥本哈根城市心脏研究是一项基于人群的队列研究。利用3次队列检查（1976年至1978年、1981年至1983年以及1991年至1994年）的基线数据，我们分析了心房颤动（AF）对5年随访期间中风风险和心血管死亡的性别特异性影响。纳入了29310名受试者的基线数据。276名受试者（110名女性和166名男性）记录有心房颤动。在平均4.7年的随访期间，共识别出635例中风，其中35例发生在有心房颤动的受试者中（22名女性和13名男性）。在调整年龄和合并症后，心房颤动对中风风险的影响在女性中（风险比7.8，95%置信区间5.8至14.3）比男性中（风险比1.7，95%置信区间1.0至3.0）高4.6倍。1122名受试者发生心血管死亡，其中63名有心房颤动（28名女性和35名男性）。心房颤动对心血管死亡率的独立影响在女性中（风险比4.4,95%置信区间2.9至6.5）比男性中（风险比2.2,95%置信区间1.6至3.1）高2.5倍。我们的结果表明，心房颤动在女性中是比男性更显著的中风和心血管死亡风险因素。
