Villarreal Gerardo, Hamilton Derek A, Graham David P, Driscoll Ira, Qualls Clifford, Petropoulos Helen, Brooks William M
New Mexico VA Healthcare System, PTSD Program (116A), 1501 San Pedro Drive SE, Albuquerque, NM 87108, USA.
Psychiatry Res. 2004 Sep 15;131(3):227-35. doi: 10.1016/j.pscychresns.2004.05.002.
Magnetic resonance imaging (MRI) studies have revealed decreases in the mid-sagittal area of the corpus callosum (CC) in pediatric posttraumatic stress disorder (PTSD), but at present no data are available in adult PTSD patients. We have previously reported decreased whole-brain white matter (WM) volume in adults with PTSD and now report corpus callosum area from the same sample. MRI was used to obtain whole-brain images in 12 adult patients with PTSD and 10 matched controls. Total parenchyma (white matter plus gray matter [GM]) volume, mid-sagittal area of the CC and seven sub-regions of this structure were calculated. In PTSD patients, the total CC area, absolute and normalized to total brain parenchyma, was smaller compared with control values. Several absolute and normalized CC sub-regions were also smaller in PTSD patients: genu (region 2), mid-body (region 5) and isthmus (region 6). There was also a trend for the anterior mid-body (area 4) to be smaller in PTSD patients. No differences were found in the rostrum (region 1), rostral body (region 3) or splenium (region 7). Adult patients with PTSD had decreased CC area after correcting for total brain tissue, indicating that these differences are not attributable to generalized white matter atrophy. These findings are similar to previous results in children with PTSD and suggest specific changes in the CC.
磁共振成像（MRI）研究显示，小儿创伤后应激障碍（PTSD）患者胼胝体（CC）的中矢状面面积减小，但目前尚无成年PTSD患者的数据。我们之前曾报道过成年PTSD患者全脑白质（WM）体积减小，现在报告同一组样本的胼胝体面积。使用MRI对12名成年PTSD患者和10名匹配的对照者进行全脑成像。计算了总实质（白质加灰质[GM]）体积、CC的中矢状面面积以及该结构的七个子区域。与对照值相比，PTSD患者的CC总面积（相对于全脑实质的绝对值和归一化值）较小。PTSD患者的几个CC子区域的绝对值和归一化值也较小：膝部（区域2）、中部（区域5）和峡部（区域6）。PTSD患者的前中部（区域4）也有变小的趋势。在嘴部（区域1）、嘴侧体（区域3）或压部（区域7）未发现差异。校正全脑组织后，成年PTSD患者的CC面积减小，这表明这些差异并非归因于全身性白质萎缩。这些发现与之前对PTSD儿童的研究结果相似，提示CC存在特定变化。
