Kurose Hitomi, Bito Takaaki, Adachi Taro, Shimizu Miyuki, Noji Sumihare, Ohuchi Hideyo
Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima, Minami-Jyosanjima, Tokushima 770-8506, Japan.
Gene Expr Patterns. 2004 Oct;4(6):687-93. doi: 10.1016/j.modgep.2004.04.005.
The normal development of eyes relies on proper signaling through Fibroblast growth factor (FGF) receptors, but the source and identity of cognate ligands have remained largely unknown. We have found that Fgf19 is expressed in the developing chicken retina. In situ hybridization discloses dynamic expression patterns for Fgf19 in the optic vesicle, lens primordia and retinal horizontal cells. Overall expression pattern of Fgf19 during chicken embryogenesis was also examined: Fgf19 is expressed in the regions associated with cranial placodes induction, boundary regions of rhombomeres, somites, specific groups of neural cells in midbrain, hindbrain, and those derived from epibranchial placodes, and the apical ectodermal ridge of limb buds. Expression pattern of the Fgf19-orthologous gene Fgf15 was further examined in the mouse developing eye. Fgf15 is expressed in the optic vesicle, a subset of progenitor cells of neural retina, and emerging ganglion and amacrine cells during retinogenesis.
眼睛的正常发育依赖于通过成纤维细胞生长因子（FGF）受体进行的适当信号传导，但同源配体的来源和身份在很大程度上仍不清楚。我们发现Fgf19在发育中的鸡视网膜中表达。原位杂交揭示了Fgf19在视泡、晶状体原基和视网膜水平细胞中的动态表达模式。我们还研究了Fgf19在鸡胚胎发育过程中的整体表达模式：Fgf19在与颅基板诱导相关的区域、菱脑节的边界区域、体节、中脑和后脑的特定神经细胞群、源自鳃上基板的细胞群以及肢芽的顶端外胚层嵴中表达。我们进一步研究了Fgf19直系同源基因Fgf15在小鼠发育眼睛中的表达模式。Fgf15在视泡、神经视网膜祖细胞的一个亚群以及视网膜发生过程中出现的神经节细胞和无长突细胞中表达。
