Oenga Gideon N, Spink David C, Carpenter David O
Wadsworth Center, New York State Department of Health, Albany, NY 12201-0509, USA.
Toxicol In Vitro. 2004 Dec;18(6):811-9. doi: 10.1016/j.tiv.2004.04.004.
The effects on cell proliferation of arylhydrocarbon receptor (AhR) agonists in estrogen-responsive T47D and ZR-75-1 cells were investigated. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and the non-ortho-substituted polychlorinated biphenyl (PCB) congeners, PCB 77, PCB 81, PCB 126, and PCB 169 each inhibited 17beta-estradiol (E(2))-stimulated cell proliferation in a dose-responsive manner. In the absence of added E(2), TCDD, PCB 77, PCB 81, and PCB 169 had no significant effect on cell proliferation, while PCB 126 at high concentrations caused slight elevations. The order of effective inhibition of E(2)-stimulated cell proliferation by the PCB congeners was: PCB 81>PCB 126 approximately = PCB 169>PCB 77. In the comparative literature, mammalian TEFs for these congeners toxic potency are in the order: PCB 126>PCB 169>PCB 81 approximately = PCB 77 [Organohalogen Compd. 34 (1997) 237]. Our results thus show an unexpected different pattern for the inhibitory effects of PCBs congeners on E(2)-mediated cell proliferation.
研究了芳烃受体（AhR）激动剂对雌激素反应性T47D和ZR-75-1细胞增殖的影响。2,3,7,8-四氯二苯并对二恶英（TCDD）以及非邻位取代的多氯联苯（PCB）同系物PCB 77、PCB 81、PCB 126和PCB 169均以剂量反应方式抑制17β-雌二醇（E₂）刺激的细胞增殖。在未添加E₂的情况下，TCDD、PCB 77、PCB 81和PCB 169对细胞增殖无显著影响，而高浓度的PCB 126会导致轻微升高。PCB同系物对E₂刺激的细胞增殖的有效抑制顺序为：PCB 81>PCB 126≈PCB 169>PCB 77。在比较文献中，这些同系物的哺乳动物毒性当量因子（TEFs）的毒性效力顺序为：PCB 126>PCB 169>PCB 81≈PCB 77 [有机卤化合物。34 (1997) 237]。因此，我们的结果显示了PCB同系物对E₂介导的细胞增殖的抑制作用存在意想不到的不同模式。
