Fujimaki Hidekazu, Kurokawa Yoshika, Kakeyama Masaki, Kunugita Naoki, Fueta Yukiko, Fukuda Takaichi, Hori Hajime, Arashidani Keiichi
National Institute for Environmental Studies, Tsukuba 305-8506, Japan.
Neuroimmunomodulation. 2004;11(6):373-5. doi: 10.1159/000080147.
The effects of low-level formaldehyde (FA) inhalation on the amount of nerve growth factor (NGF) in the hippocampus of immunized mice were studied.
Evaluation of NGF in the hippocampus was performed by ELISA and RT-PCR.
Exposure to 80 and 400 ppb FA significantly increased the brain NGF levels in the immunized mice. Evaluation of the NGF levels in the hippocampus of immunized mice showed that 400 ppb FA significantly increased the NGF content. The RT-PCR evaluation also showed higher concentrations of hippocampal NGF mRNA in the mice exposed to 80 and 400 ppb FA with immunization.
Exposure of immunized mice to low levels of FA significantly increases NGF levels in the hippocampus.
研究低水平甲醛（FA）吸入对免疫小鼠海马中神经生长因子（NGF）含量的影响。
采用酶联免疫吸附测定（ELISA）和逆转录-聚合酶链反应（RT-PCR）对海马中的NGF进行评估。
暴露于80和400 ppb FA的免疫小鼠脑内NGF水平显著升高。对免疫小鼠海马中NGF水平的评估显示，400 ppb FA显著增加了NGF含量。RT-PCR评估还显示，暴露于80和400 ppb FA并免疫的小鼠海马中NGF mRNA浓度更高。
免疫小鼠暴露于低水平FA会显著增加海马中的NGF水平。
