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牛用注射用恩诺沙星口服凝胶制剂在马体内的药代动力学、稳定性及使用情况回顾性分析

Pharmacokinetics, stability, and retrospective analysis of use of an oral gel formulation of the bovine injectable enrofloxacin in horses.

作者信息

Epstein Kira, Cohen Noah, Boothe Dawn, Nieuwoudt Cornelia, Chandler Jeff

机构信息

Department of Clinical Studies, New Bolton Center, University of Pennsylvania, Kennett Square, PA, USA.

出版信息

Vet Ther. 2004 Summer;5(2):155-67.

PMID:15468012
Abstract

In many cases of equine infectious disease, long-term administration of antimicrobial drugs is required. Oral agents are preferred because of the relative ease of administration compared with other routes. Enrofloxacin has been shown to be effective against a variety of equine pathogens, but oral administration of this drug has proved difficult in horses. An oral gel formulation made from the injectable cattle product produces blood levels sufficient to resolve infections caused by a variety of common equine pathogens.

摘要

在许多马传染病病例中,需要长期使用抗菌药物。口服制剂更受青睐,因为与其他给药途径相比,其给药相对容易。恩诺沙星已被证明对多种马病原体有效,但事实证明,在马身上口服这种药物很困难。一种由可注射牛用产品制成的口服凝胶制剂产生的血药浓度足以解决由多种常见马病原体引起的感染。

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