遗传性毛发和指甲疾病的分子遗传学

Molecular genetics of hereditary hair and nail disease.

作者信息

van Steensel M A M, van Geel M, Steijlen P M

机构信息

Dermatology Department, University Hospital Maastricht, the Netherlands.

出版信息

Am J Med Genet C Semin Med Genet. 2004 Nov 15;131C(1):52-60. doi: 10.1002/ajmg.c.30034.

DOI:10.1002/ajmg.c.30034

PMID:15468149

Abstract

Hair and nail development have many similarities and are likely to share many developmental pathways. This is evident from the ectodermal dysplasias that affect both appendages. Of special interest are syndromic disorders as they show the effects of disturbances in molecular pathways that are essential for normal embryonic development. In this review, recent results from studies of syndrome affecting hair and nail development will be discussed.

摘要

毛发和指甲的发育有许多相似之处，并且可能共享许多发育途径。这在影响这两种附属器的外胚层发育异常中很明显。特别值得关注的是综合征性疾病，因为它们显示了对正常胚胎发育至关重要的分子途径紊乱所产生的影响。在这篇综述中，将讨论影响毛发和指甲发育的综合征研究的最新结果。