通过原子转移自由基聚合（ATRP）和α-氨基酸-N-羧酸酐的活性聚合合成AB二嵌段共聚物。

Synthesis of AB diblock copolymers by atom-transfer radical polymerization (ATRP) and living polymerization of alpha-amino acid-N-carboxyanhydrides.

作者信息

Brzezinska Krystyna R, Deming Timothy J

机构信息

Materials Research Laboratory, Chemistry Department, University of California, Santa Barbara, Santa Barbara, California 93106, USA.

出版信息

Macromol Biosci. 2004 Jun 25;4(6):566-9. doi: 10.1002/mabi.200400030.

DOI:10.1002/mabi.200400030

PMID:15468248

Abstract

The synthesis of poly(methyl acrylate)-block-poly(gamma-benzyl-L-glutamate) (PMA-b-PBLG) diblock copolymers, using atom-transfer radical polymerization (ATRP) of methyl acrylate and living polymerization of gamma-benzyl-L-glutamate-N-carboxyanhydride (Glu-NCA) is described. Amido-amidate nickelacycle end groups were incorporated onto amino-terminated poly(methyl acrylates), and the resulting complexes were successfully used as macroinitiators for the growth of polypeptide segments. This method allows the controlled preparation of polypeptide-block-poly(methyl acrylate) diblock architectures with control over polypeptide chain length and without the formation of homopolypeptide contaminants.

摘要

描述了通过丙烯酸甲酯的原子转移自由基聚合（ATRP）和γ-苄基-L-谷氨酸-N-羧基酐（Glu-NCA）的活性聚合来合成聚（丙烯酸甲酯）-嵌段-聚（γ-苄基-L-谷氨酸）（PMA-b-PBLG）二嵌段共聚物。酰胺-酰胺镍环端基被引入到氨基封端的聚（丙烯酸甲酯）上，所得配合物成功用作多肽链段生长的大分子引发剂。该方法能够可控地制备多肽-嵌段-聚（丙烯酸甲酯）二嵌段结构，可控制多肽链长度且不形成均聚多肽污染物。