Wang Shi-Bin, Chen Ai-Zheng, Weng Lian-Jin, Chen Mei-Ying, Xie Xiao-Lin
College of Materials Science and Engineering, Huaqiao University, Quanzhou, Fujian 362011, China.
Macromol Biosci. 2004 Jan 21;4(1):27-30. doi: 10.1002/mabi.200300043.
The drug-loaded alginate/poly-L-arginine/chitosan ternary complex microcapsules were prepared by mixing method, absorption method and the combined method of mixing and absorption, respectively. The effect of drug-loading methods on drug load, the encapsulation efficiency and the release properties of the complex microcapsules were investigated. The results showed that the absorption process is a dominating factor to greatly increase the drug load of Hb into microcapsules. Upon loading Hb into microcapsules by combined method of mixing and absorption, the drug load (19.9%) is up to the maximum value, and the encapsulation efficiency is 93.8%. Moreover, the drug release is a zero-order kinetics process for the ternary complex microcapsules made by mixing. For the complex microcapsules made by absorption, the drug release is a first-order kinetics. However, for the complex microcapsules made by combining the mixing and the absorption, the drug release obeys a first-order kinetics during the first eighteen hours, changing afterwards to a zero-order kinetics process. Effect of drug-loading methods on drug load and encapsulation efficiency of alginate/poly-L-arginine/chitosan ternary complex microcapsules.
载药海藻酸盐/聚-L-精氨酸/壳聚糖三元复合微胶囊分别采用混合法、吸附法以及混合与吸附相结合的方法制备。考察了载药方法对复合微胶囊载药量、包封率及释放性能的影响。结果表明，吸附过程是大幅提高微胶囊中血红蛋白载药量的主要因素。采用混合与吸附相结合的方法将血红蛋白载入微胶囊时，载药量（19.9%）达到最大值，包封率为93.8%。此外，混合法制备的三元复合微胶囊的药物释放为零级动力学过程。吸附法制备的复合微胶囊的药物释放为一级动力学。然而，对于混合与吸附相结合法制备的复合微胶囊，药物在最初18小时内的释放符合一级动力学，之后转变为零级动力学过程。载药方法对海藻酸盐/聚-L-精氨酸/壳聚糖三元复合微胶囊载药量及包封率的影响。
