Attfield M D, Hodous T K
Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505.
Am Rev Respir Dis. 1992 Mar;145(3):605-9. doi: 10.1164/ajrccm/145.3.605.
This study of 7,139 U.S. coal miners used linear regression analysis to relate estimates of cumulative dust exposure to several pulmonary function variables measured during medical examinations undertaken between 1969 and 1971. The exposure data included newly derived cumulative dust exposure estimates for the period up to time of examination based on large data bases of underground airborne dust sampling measurements. Negative associations were found between measures of cumulative exposure and FEV1, FVC, and the FEV1/FVC ratio (p less than 0.001). In general, the relationships were similar to those reported for British coal miners. Overall, the results demonstrate an adverse effect of coal mine dust exposure on pulmonary function that occurs even in the absence of radiographically detected pneumoconiosis.
这项针对7139名美国煤矿工人的研究采用线性回归分析，将累积粉尘暴露估计值与1969年至1971年期间医学检查中测量的多个肺功能变量相关联。暴露数据包括基于地下空气中粉尘采样测量的大型数据库得出的截至检查时的新累积粉尘暴露估计值。累积暴露量测量值与第一秒用力呼气容积（FEV1）、用力肺活量（FVC）以及FEV1/FVC比值之间存在负相关（p<0.001）。总体而言，这些关系与英国煤矿工人的报告相似。总的来说，结果表明即使在X线检查未发现尘肺病的情况下，煤矿粉尘暴露对肺功能也有不良影响。
