Section of Occupational Medicine, Respiratory Diseases and Toxicology, University of Perugia, Perugia, Italy.
Respirology. 2022 Jun;27(6):399-410. doi: 10.1111/resp.14272. Epub 2022 May 5.
Chronic obstructive pulmonary disease (COPD) is caused by exposure to noxious particles and gases. Smoking is the main risk factor, but other factors are also associated with COPD. Occupational exposure to vapours, gases, dusts and fumes contributes to the development and progression of COPD, accounting for a population attributable fraction of 14%. Workplace pollutants, in particular inorganic dust, can initiate airway damage and inflammation, which are the hallmarks of COPD pathogenesis. Occupational COPD is still underdiagnosed, mainly due to the challenges of assessing the occupational component of the disease in clinical settings, especially if other risk factors are present. There is a need for specific education and training for clinicians, and research with a focus on evaluating the role of occupational exposure in causing COPD. Early diagnosis and identification of occupational causes is very important to prevent further decline in lung function and to reduce the health and socio-economic burden of COPD. Establishing details of the occupational history by general practitioners or respiratory physicians could help to define the occupational burden of COPD for individual patients, providing the first useful interventions (smoking cessation, best therapeutic management, etc.). Once patients are diagnosed with occupational COPD, there is a wide international variation in access to specialist occupational medicine and public health services, along with limitations in workplace and income support. Therefore, a strong collaboration between primary care physicians, respiratory physicians and occupational medicine specialists is desirable to help manage COPD patients' health and social issues.
慢性阻塞性肺疾病(COPD)是由有害物质颗粒和气体暴露引起的。吸烟是主要的危险因素,但其他因素也与 COPD 相关。职业暴露于蒸气、气体、粉尘和烟雾会促进 COPD 的发展和进展,占人群归因分数的 14%。工作场所污染物,特别是无机粉尘,可引发气道损伤和炎症,这是 COPD 发病机制的标志。职业性 COPD 仍未得到充分诊断,主要是由于在临床环境中评估疾病的职业因素具有挑战性,特别是如果存在其他危险因素。临床医生需要接受专门的教育和培训,需要开展研究以评估职业暴露在导致 COPD 方面的作用。早期诊断和识别职业原因对于防止肺功能进一步下降以及降低 COPD 的健康和社会经济负担非常重要。全科医生或呼吸科医生详细了解职业史,可以帮助确定个体患者的 COPD 职业负担,提供最初的有用干预措施(戒烟、最佳治疗管理等)。一旦患者被诊断为职业性 COPD,他们获得专科职业医学和公共卫生服务的机会以及工作场所和收入支持方面存在广泛的国际差异。因此,理想情况下,初级保健医生、呼吸科医生和职业医学专家之间应密切合作,以帮助管理 COPD 患者的健康和社会问题。