H2复合体和非H2基因对感染亚马逊利什曼原虫的小鼠皮肤病变进展的影响。

Influence of H2 complex and non-H2 genes on progression of cutaneous lesions in mice infected with Leishmania amazonensis.

作者信息

Terabe Masaki, Wakana Shigeharu, Katakura Ken, Onodera Takashi, Matsumoto Yoshitsugu, Ito Mamoru

机构信息

Department of Molecular Immunology, School of Agriculture and Life Sciences, University of Tokyo 113-6857, Japan.

出版信息

Parasitol Int. 2004 Sep;53(3):217-21. doi: 10.1016/j.parint.2003.12.002.

DOI:10.1016/j.parint.2003.12.002

PMID:15468528

Abstract

Susceptibility to infection with Leishmania amazonensis promastigotes was examined in six B10 congenic mouse strains, including C57BL/10J (H2b), B10.BR (H2k), B10.M (H2f), B10.S (H2s), B10.RIII (H2r), and B10.D2 (H2d). All strains of mice developed skin nodules with punch-out ulcers by 8 weeks post-infection, but B10.M and B10.S mice showed resolution of cutaneous leishmaniasis lesions by 16 weeks post-infection. In addition, the skin lesions were much larger in BALB congenic mice than in B10 and C3H mice, even though these mice share the same H2 haplotypes. These results suggest that H2 complex controls the growth of L. amazonensis in cutaneous lesions, and that non-H2 genes inherited by BALB congenic mice have a more potent role than the H2 complex in lesion progression.

摘要

在六种B10同源近交系小鼠中检测了对亚马逊利什曼原虫前鞭毛体感染的易感性，包括C57BL/10J（H2b）、B10.BR（H2k）、B10.M（H2f）、B10.S（H2s）、B10.RIII（H2r）和B10.D2（H2d）。所有品系的小鼠在感染后8周都出现了伴有穿孔性溃疡的皮肤结节，但B10.M和B10.S小鼠在感染后16周皮肤利什曼病病变消退。此外，尽管BALB同源近交系小鼠与B10和C3H小鼠具有相同的H2单倍型，但前者的皮肤病变比后两者大得多。这些结果表明，H2复合体控制皮肤病变中亚马逊利什曼原虫的生长，并且BALB同源近交系小鼠继承的非H2基因在病变进展中比H2复合体发挥更重要的作用。