[Diastolic malfunction in sepsis and septic shock].

The onset and development of cardiac insufficiency is associated with diverse pathophysiological mechanisms with attention being focused recently on studying the significance of "proinflammatory" cytokines, primarily, of TNFalpha. Fifty-nines patients (age--18-24, body weight--54-76) with sepsis (19 persons, group 1), severe sepsis (20 persons, group 2) and with septic shock (20 persons, group 3) were examined. The mechanic function of the left cardiac ventricle and hemodynamic parameters were evaluated by a routine scheme in the modes of 1D (M-echo-cardiography) and sector scanning (2D echo-cardiography) at the SIM-5000 device (Italy). The central hemodynamic indices were investigated by integral tetrapolar rheography according to Tishchenko. The results denote a big significance of diastolic malfunction of the left cardiac ventricle or "rigid" myocardium in shaping of myocardial malfunction as observed in sepsis and septic shock.