Woods Andrew, Hobson Philip, Klavinskis Linda S
Kings College London, Guy's, King's and St Thomas' School of Medicine, Peter Gorer Department of Immunobiology, St Thomas Street, London, SE1 9RT, UK.
Curr Opin Mol Ther. 2004 Aug;6(4):395-402.
Rheumatoid arthritis is a debilitating systemic autoimmune disease characterized by chronic synovial inflammation, which results in the progressive destruction of diseased joints. Advances in understanding the disease pathogenesis have led to the clinical introduction of biological inhibitors of inflammation or articular destruction. However, frequency of administration, cost and systemic side effects have driven efforts to develop gene therapeutic transfer strategies. This article reviews recent progress in the application of viral and non-viral vectors to target therapeutic genes for in vivo delivery.
类风湿性关节炎是一种使人衰弱的全身性自身免疫性疾病，其特征为慢性滑膜炎症，会导致患病关节的渐进性破坏。在了解该疾病发病机制方面的进展已促使临床上引入炎症或关节破坏的生物抑制剂。然而，给药频率、成本和全身副作用推动了开发基因治疗传递策略的努力。本文综述了病毒载体和非病毒载体在体内递送靶向治疗基因应用方面的最新进展。
