McKeown Stephanie R, Ward Claire, Robson Tracy
University of Ulster at Coleraine, Radiation Science Group, School of Biomedical Sciences, Centre for Molecular Biosciences, Cromore Road, Coleraine, Co Londonderry, Northern Ireland.
Curr Opin Mol Ther. 2004 Aug;6(4):421-35.
Gene-directed enzyme prodrug therapy involves tumor-specific delivery of a gene encoding a drug-metabolizing enzyme allowing metabolism of a non-toxic prodrug to a toxic species directly within tumor cells. This review covers the wide range of enzyme-prodrug combinations currently under preclinical and clinical investigation. Issues of tumor specificity and enhanced cytotoxicity through bystander effects will be discussed.
基因导向酶前药疗法涉及肿瘤特异性递送一种编码药物代谢酶的基因，使无毒前药在肿瘤细胞内直接代谢为有毒物质。本综述涵盖了目前正处于临床前和临床研究阶段的广泛的酶-前药组合。还将讨论肿瘤特异性问题以及通过旁观者效应增强细胞毒性的问题。
