在用于人类软骨工程的血清耗尽培养基中，胰岛素样生长因子-1与其他生长因子之间的相互作用。
Interaction between insulin-like growth factor-1 with other growth factors in serum depleted culture medium for human cartilage engineering.
作者信息
Chua K H, Aminuddin B S, Fuzina N H, Ruszymah B H I
机构信息
Department of Physiology, Medical Faculty of Universiti Kebangsaan Malaysia.
出版信息
Med J Malaysia. 2004 May;59 Suppl B:7-8.
The regulation roles of insulin-like growth factor-1 (IGF-1) with basic fibroblast growth factor (bFGF) and transforming growth factor beta 2 (TGFbeta2) in human nasal septum chondrocytes monolayer culture and cartilage engineering was investigated in this study. The role of IGF-1 with bFGF and TGFbeta2 was investigated by measuring chondrocyte growth kinetic and collagen genes expression. IGF-1 together with bFGF and TGFbeta2 promote cartilage tissue engineering, increase type II collagen expression and enhance the histological features of engineered cartilage.
本研究探讨了胰岛素样生长因子-1（IGF-1）与碱性成纤维细胞生长因子（bFGF）和转化生长因子β2（TGFβ2）在人鼻中隔软骨细胞单层培养和软骨工程中的调节作用。通过测量软骨细胞生长动力学和胶原蛋白基因表达来研究IGF-1与bFGF和TGFβ2的作用。IGF-1与bFGF和TGFβ2共同促进软骨组织工程，增加II型胶原蛋白表达并增强工程软骨的组织学特征。
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