骨髓干细胞在骨组织工程中的应用。
The use of bone marrow stem cells for bone tissue engineering.
作者信息
Ng M H Angela, Aminuddin B S, Tan K K, Tan G H, Sabarul Afian M, Ruszymah B H I
机构信息
Tissue Engineering Laboratory, Hospital Universiti Kebangsaan Malaysia.
出版信息
Med J Malaysia. 2004 May;59 Suppl B:41-2.
Bone marrow stem cells (BMSC), known for its multipotency to differentiate into various mesenchymal cells such as chodrocyte, osteoblasts, adipocytes, etc, have been actively applied in tissue engineering. BMSC have been successfully isolated from bone marrow aspirate and bone marrow scraping from patients of various ages (13-56 years) with as little as 2ml to 5ml aspirate. BMSC isolated from our laboratory showed the presence of a heterogenous population that showed varying prevalence of surface antigens and the presence of telomerase activity albeit weak. Upon osteogenic induction, alkaline phosphatase activity and mineralization activity were observed.
骨髓干细胞（BMSC）以其多能性而闻名，能够分化为各种间充质细胞，如软骨细胞、成骨细胞、脂肪细胞等，已被积极应用于组织工程。已成功从不同年龄（13 - 56岁）患者的骨髓抽吸物和骨髓刮除物中分离出BMSC，抽吸物少至2毫升至5毫升。从我们实验室分离出的BMSC显示存在异质群体，其表面抗原的流行率各不相同，并且存在端粒酶活性，尽管较弱。在成骨诱导后，观察到碱性磷酸酶活性和矿化活性。
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