Kokubo T
Research Institute for Science and Technology, Chubu University, 1200 Matsumoto-cho 487-8501 Kasugai Japan.
Med J Malaysia. 2004 May;59 Suppl B:91-2.
Metallic materials implanted into bone defects are generally encapsulated by a fibrous tissue. Some metallic materials such as titanium and tantalum, however, have been revealed to bond to the living bone without forming the fibrous tissue, when they were subjected to NaOH solution and heat treatments. Thus treated metals form bone tissue around them even in muscle, when they take a porous form. This kind of osteoconductive and osteoinductive properties are attributed to sodium titanate or tantalate layer on their surfaces formed by the NaOH and heat treatments. These layers induce the deposition of bonelike apatite on the surface of the metals in the living body. This kind of bioactive metals are useful as bone substitutes even highly loaded portions, such as hip joint, spine and tooth root.
植入骨缺损部位的金属材料通常会被纤维组织包裹。然而，一些金属材料，如钛和钽，在经过氢氧化钠溶液和热处理后，已被发现能够与活骨结合而不形成纤维组织。经过如此处理的金属，当其呈多孔形式时，即使在肌肉中也会在其周围形成骨组织。这种骨传导性和骨诱导性特性归因于通过氢氧化钠和热处理在其表面形成的钛酸钠或钽酸盐层。这些层会诱导活体中金属表面形成类骨磷灰石的沉积。这种生物活性金属即使在诸如髋关节、脊柱和牙根等高负荷部位也可用作骨替代物。
