Grigorenko N A, Vepsalainen J, Jarvinen A, Keinanen T A, Alhonen L, Janne J, Kritsyn A M, Khomutov A R
Bioorg Khim. 2004 Jul-Aug;30(4):441-5. doi: 10.1023/b:rubi.0000037268.98349.ce.
A five-step synthesis of alpha-methylspermidine (1,8-diamino-5-azanonane), the first polyamine analogue preventing pathological consequences of spermidine depletion in transgenic rats overproducing spermine/spermidine N'-acetyltransferase, from ethyl 3-aminobutyrate was achieved in a high overall yield.
以3-氨基丁酸乙酯为原料，通过五步合成法高效合成了α-甲基亚精胺（1,8-二氨基-5-氮杂壬烷），这是首个能够预防在过量产生精胺/亚精胺N'-乙酰转移酶的转基因大鼠中亚精胺耗竭所导致的病理后果的多胺类似物。
