Li Lian, Wang Gen-Lin
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095.
Sheng Li Ke Xue Jin Zhan. 2004 Jul;35(3):215-8.
The pulsatile pattern of the hypothalamic hormone gonadotropin-releasing hormone (GnRH) plays a critical role in reproductive function by regulating the biosynthesis and secretion of the pituitary gonadotropins. Follicle-stimulating hormone (FSH) and Luteinizing hormone (LH) are heterodimeric glycoproteins composed of a common peptide, the glycoprotein hormone subuint alpha, and either a specific FSHbeta or LHbeta polypeptide. GnRH regulates LHbeta gene expression through GnRH receptor activation of the protein kinase C (PKC) and calcium signaling cascades. Recently, many transcription factors, such as early growth response-1 (Egr-1), steroidogenic factor-1 (SF-1), Ptx1 and Sp1, have been recognized to be involved in expression of the LHbeta gene through binding to the promoter region of LHbeta gene.
下丘脑激素促性腺激素释放激素（GnRH）的脉冲模式通过调节垂体促性腺激素的生物合成和分泌，在生殖功能中发挥关键作用。卵泡刺激素（FSH）和黄体生成素（LH）是异源二聚体糖蛋白，由一个共同的肽即糖蛋白激素亚基α和特定的FSHβ或LHβ多肽组成。GnRH通过蛋白激酶C（PKC）和钙信号级联的GnRH受体激活来调节LHβ基因表达。最近，许多转录因子，如早期生长反应因子-1（Egr-1）、类固醇生成因子-1（SF-1）、Ptx1和Sp1，已被认为通过与LHβ基因的启动子区域结合而参与LHβ基因的表达。
