Zhang Mei, Li Xiao-Mei
Renal Division, Department of Medicine, First Hospital and Institute of Nephrology, Peking University, Beijing 100034.
Sheng Li Ke Xue Jin Zhan. 2004 Jul;35(3):219-23.
It is an important cell biological phenomenon that epithelial cells transit into mesenchymal cells under special physiological and pathological condition. In recent years, it has been known that epithelial-mesenchymal-transition may be mediated by several intracellular signaling pathways, such as MAPK, Rho, Src, PI3 kinase and Smads. Renal tubular epithelial cells have been observed to transit to myo-fibroblasts in renal diseases. However, the intracellular signaling pathways are rarely known. The progress on this field is reviewed.
上皮细胞在特殊的生理和病理条件下转变为间充质细胞是一种重要的细胞生物学现象。近年来，人们已经知道上皮-间质转化可能由几种细胞内信号通路介导，如丝裂原活化蛋白激酶（MAPK）、Rho、Src、磷脂酰肌醇-3激酶（PI3激酶）和Smad蛋白。在肾脏疾病中，已观察到肾小管上皮细胞转变为肌成纤维细胞。然而，细胞内信号通路却鲜为人知。本文对该领域的进展进行综述。
