Marson P, Zanchin G, Stefanutti C
Unità di Emocitoaferesi, Servizio Immunotrasfusionale, Azienda Ospedaliera di Padova.
Reumatismo. 2004 Jul-Sep;56(3):215-9. doi: 10.4081/reumatismo.2004.215.
In the past 20 years several clinical and experimental observations have led to the hypothesis that an inflammatory response can trigger some key processes during the development of atherosclerosis. Here we briefly review, from the historical viewpoint, the inflammatory theory of atherosclerosis, as proposed by the Berliner pathologist Rudolf Virchow in the XIX century. Contrary to this hypothesis, in the same period the Viennese Karl von Rokitansky recognized blood dyscrasia (particularly fibrin-induced alterations) as the promoting factor in the process of atherogenesis. Moreover, we outline the relationship between atherosclerosis and arthritis, by reporting some passages from two scientific works published in the late XIX century, the former by the Italian Achille De Giovanni ("Sull'arterite. Sue forme cliniche e sua patogenesi", 1882) and the latter by the French Theophile Guyot ("L'arthritis. Maladie Constitutionnelle", 1890).
在过去20年里，一些临床和实验观察结果引发了这样一种假说：炎症反应可能在动脉粥样硬化发展过程中触发某些关键进程。在此，我们从历史角度简要回顾19世纪由柏林病理学家鲁道夫·魏尔啸提出的动脉粥样硬化炎症理论。与这一假说相反，同一时期维也纳的卡尔·冯·罗基坦斯基认为血液恶病质（尤其是纤维蛋白引起的改变）是动脉粥样硬化形成过程中的促进因素。此外，我们通过引用19世纪末发表的两篇科学著作中的一些段落，概述动脉粥样硬化与关节炎之间的关系，前者是意大利人阿基莱·德·乔瓦尼所著（《论动脉炎。其临床形式及其发病机制》，1882年），后者是法国人西奥菲勒·居约所著（《关节炎。体质性疾病》，1890年）。
