Neagoe Adina, Molnar Ana-Maria, Acalovschi Monica, Seicean Andrada, Serban Alexandru
3rd Medical Clinic, Str. Croitorilor 19-21, 400162 Cluj-Napoca, Romania.
Rom J Gastroenterol. 2004 Sep;13(3):187-93.
The purpose of the research was to evaluate several risk factors for colonic neoplasia and to institute a specialized colorectal cancer (CRC) registry in the 3rd Medical and Surgical Clinics Cluj-Napoca.
The study comprised 333 patients,155 women, mean age 61.32 +/- 12.42 years and 178 men, mean age 64.31 +/- 10.39 years, admitted to the 3rd Medical Clinic and 3rd Surgical Clinic Cluj-Napoca and diagnosed with CRC between January 2001 - September 2003. The diagnosis was made on the basis of clinical, endoscopical and histopathological findings. Age, geographical patterns, tumor location, family history, personal history and several lifestyle factors: dietary habits (intake of fat and red meat), long term smoking (more than 20 years), heavy alcohol consumption were analyzed. Evaluation was made using family history and epidemiologic lifestyle questionnaires.
CRC occurred more frequently in the 7th decade. There was a strong correlation between age and CRC development. In the 5th decade, females developed CRC more frequently than males. The median age for developing right-sided tumors was significantly higher in males. Patients living in an urban area were dominant (69%). Family history was present in 1/3 of females and 1/4 of males. Personal history of colon polyps was more common in men, particularly among smokers for more than 20 years and among those with an excessive intake of fat. The cholecystectomized women had an increased frequency of sigmoidian tumors. All the patient's information was included in a specialized colon cancer registry.
High fat intake and cigarette smoking favour colon polyp development. CRC development and location of the tumor are associated with an older age (in men) and personal history of cholecystectomy (in women). Inheritance was significant in our study group.
本研究旨在评估结肠肿瘤的几种风险因素，并在克卢日 - 纳波卡第三内科和外科诊所建立一个专门的结直肠癌（CRC）登记处。
该研究纳入了333例患者，其中155例女性，平均年龄61.32±12.42岁，178例男性，平均年龄64.31±10.39岁，他们于2001年1月至2003年9月期间入住克卢日 - 纳波卡第三内科诊所和第三外科诊所，并被诊断为结直肠癌。诊断基于临床、内镜和组织病理学检查结果。分析了年龄、地理模式、肿瘤位置、家族史、个人史以及几种生活方式因素：饮食习惯（脂肪和红肉摄入量）、长期吸烟（超过20年）、大量饮酒。使用家族史和流行病学生活方式问卷进行评估。
结直肠癌在70岁年龄段更为常见。年龄与结直肠癌的发生之间存在很强的相关性。在50岁年龄段，女性患结直肠癌的频率高于男性。男性发生右侧肿瘤的中位年龄明显更高。居住在城市地区的患者占主导（69%）。1/3的女性和1/4的男性有家族史。结肠息肉个人史在男性中更为常见，尤其是在吸烟超过20年以及脂肪摄入量过多的人群中。接受胆囊切除术的女性患乙状结肠肿瘤的频率增加。所有患者的信息都被纳入了一个专门的结肠癌登记处。
高脂肪摄入和吸烟有利于结肠息肉的发展。结直肠癌的发生和肿瘤位置与年龄较大（男性）和胆囊切除术个人史（女性）有关。在我们的研究组中，遗传因素具有重要意义。
