Kitchen Ian
University of Surrey, Department of Biological Sciences, Guildford, Surrey, GU2 5XH, UK.
IDrugs. 2004 Sep;7(9):811-4.
Research in the opioid field underwent a lull in the 1990's but much new research has recently been stimulated, firstly by the cloning of all of the opioid receptors and then by the development of gene knockout mice and their phenotype characterization. These developments have led to a a reappraisal of the potential utility of opioid agonists and antagonists not only for the treatment of pain but also for mood-related conditions and peripheral indications. Medicinal chemistry groups are still moving the field forward, and the pharmaceutical industry continues to keep a watching brief. Opioids are no longer exclusively the province of pain scientists, and potential for treatment of limbic disorders, itch and addiction are only now beginning to be considered seriously.
20世纪90年代，阿片类药物领域的研究陷入停滞，但最近有许多新研究受到了推动，首先是所有阿片受体的克隆，然后是基因敲除小鼠的培育及其表型特征分析。这些进展促使人们重新评估阿片类激动剂和拮抗剂的潜在用途，它们不仅可用于治疗疼痛，还可用于治疗与情绪相关的病症和外周适应症。药物化学团队仍在推动该领域向前发展，制药行业也持续密切关注。阿片类药物不再仅仅是疼痛科学家的研究范畴，治疗边缘系统疾病、瘙痒和成瘾的潜力直到现在才开始得到认真考虑。
