Hetzel G, Moeller O, Erfurth A, Michael N, Rothermundt M, Arolt V, Evers S
Department of Psychiatry, University of Muenster, Muenster, Germany.
Pharmacopsychiatry. 2004 Sep;37(5):200-5. doi: 10.1055/s-2004-827244.
The aim of our study was to assess the possible relationship between event-related potentials (ERP) and serotonergic or noradrenergic activity in depression. Therefore, we were interested in the impact of different monoamine reuptake inhibitors on ERP.
Thirty-six inpatients with major depression were treated with either reboxetine (n = 17) or citalopram (n = 19) in a prospective randomized study. Before and after four weeks of treatment, visually-evoked ERP were investigated. Twenty-two patients completed the study. Monoaminergic function was determined by oral reboxetine and citalopram challenge tests.
P3 latency significantly decreased after a four-week treatment with either drug. There was no significant difference in the decrease of P3 latency between both drugs. We detected a significant inverse correlation between serotonergic hypofunction before treatment and the P3 latency (r = -0.739, p = 0.001).
These results show that, in depressed patients, the P3 latency is decreased by antidepressive treatment. Furthermore, the results suggest that P3 latency might depend on the serotonergic rather than the noradrenergic system.
我们研究的目的是评估事件相关电位（ERP）与抑郁症中血清素能或去甲肾上腺素能活性之间的可能关系。因此，我们关注不同单胺再摄取抑制剂对ERP的影响。
在一项前瞻性随机研究中，36例重度抑郁症住院患者接受瑞波西汀（n = 17）或西酞普兰（n = 19）治疗。在治疗四周前后，对视觉诱发ERP进行研究。22例患者完成了研究。通过口服瑞波西汀和西酞普兰激发试验确定单胺能功能。
两种药物治疗四周后，P3潜伏期均显著缩短。两种药物在P3潜伏期缩短方面无显著差异。我们检测到治疗前血清素能功能减退与P3潜伏期之间存在显著负相关（r = -0.739，p = 0.001）。
这些结果表明，在抑郁症患者中，抗抑郁治疗可使P3潜伏期缩短。此外，结果提示P3潜伏期可能取决于血清素能系统而非去甲肾上腺素能系统。
